![]() ![]() 1 Among people with CIS, lower age of onset was associated with an increased risk of conversion to clinically definite MS (CDMS). 1 Although lower age at onset is associated with a longer time to onset of disability milestone, individuals who present with MS earlier in life often acquire significant disability at an earlier age compared with individuals with onset later in life. In this review, we discuss potential prognostic factors in MS, including demographics, clinical characteristics, MRI measures, and laboratory tests that may have utility in clinical practice to predict conversion of clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) to MS (Table 1) and disease activity and disability accumulation (Table 2).Īge at MS onset is known to impact MS disease course, and increasing age at onset correlates with decreased time to onset of specific disability milestones (eg, Expanded Disability Status Scale scores of 4.0, 6.0 and 7.0). With the broad and continually increasing armamentarium of MS disease-modifying treatments (DMTs), there is an opportunity to tailor treatment decisions on an individual level to optimize clinical outcomes. Owing to the clinical heterogeneity of MS, an awareness of key features that have predictive value to identify those with a higher likelihood of having highly active disease and developing rapid disability accumulation is crucial to optimizing clinical outcomes over time. We know there are many people who have been living with lupus for 15, 25, 30 and even 40 years.Multiple sclerosis (MS) is a chronic, inflammatory, predominantly demyelinating condition of the central nervous system (CNS) that has a wide range of presentations, disease courses, and treatment responses. They did not continue to follow these patients to look at what happened in years 11, 12, 15, 20 and so on. ![]() At the end of this research period, researchers were able to conclude that 80-90% of the people enrolled were still alive. These studies followed patients with lupus from the time of diagnosis for a period of ten years. ![]() It is important to understand that the "10 years" used in this context does not represent the number of years the person lived after their diagnosis, but rather the number of years involved in the study. ![]() Research that shows 80-90% of people with lupus live for more than 10 years is often misinterpreted as giving people with lupus only 10 years to live. Some confusion about lupus life expectancy relates to the way research is communicated. A common misperception about life expectancy It is therefore a sensible idea to maintain control of a disease that tomorrow may be curable. The progress made in treatment and diagnosis during the last decade has been greater than that made over the past 100 years. New research brings unexpected findings each year.
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